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Instantly confirm the integrity of vaccines and biospecimens against heat exposure.
Freezer-level monitoring tracks the unit, not the sample. CryoVeritas indicators placed inside each storage box close the gap between facility data and specimen-level certainty.
Temperature probes measure air at a single point inside the freezer. CryoVeritas indicators sit inside the box alongside your samples, reflecting the actual thermal history of the specimens themselves — not the unit.
CAP, CLIA, and GLP auditors expect documented proof that specimens maintained required conditions. A tamper-evident, non-reversible color change provides immediate, photographable evidence for every box.
A single undetected freezer excursion can silently compromise thousands of samples collected over decades. The cost of an indicator per box is trivial compared to the cost of lost clinical trial material, longitudinal cohort specimens, or rare biospecimens.
No batteries, no software, no annual calibration schedules. Activate with a twist, place in the box, and read the result visually at retrieval. Your team can deploy indicators across an entire repository in a single afternoon.
Once activated, indicators remain functional for over two years at cryogenic temperatures. Deploy once at archival and get continuous protection through retrieval — whether that's next month or years from now.
The only temperature indicator that's user-activated, stores with samples down to −200 °C, and can be configured to signal breaches in as little as 5 minutes or as long as 48+ hours, truly mirroring how your specimens degrade.
Unlike competitive indicators that start reacting at manufacture, CryoVeritas indicators remain dormant until you activate them. This eliminates false positives and gives you full control over monitoring start time.
Competitive products offer a single fixed response time, typically 5 minutes at the signal temperature. CryoVeritas indicators are tunable from 5 minutes to 48+ hours at the same threshold, matching the actual degradation kinetics of your specific specimens.
DNA, RNA, proteins, and cells don't degrade instantly at a threshold. They follow time-dependent kinetics. CryoVeritas is the only indicator designed to mimic these degradation curves, giving you a biologically relevant signal instead of an arbitrary alarm.
A brief excursion to −60°C doesn't destroy an mRNA vaccine, but sustained exposure does. The same is true for extracted DNA, vitrified embryos, and CAR-T cell preparations. Damage is cumulative, following Arrhenius-type kinetics.
CryoVeritas indicators are engineered to integrate both time and temperature, providing a biologically meaningful signal that tells you whether your specimens are still viable, not just whether a freezer door was left open.
From −196°C liquid nitrogen to −20°C distribution, CryoVeritas covers the full spectrum of critical temperature monitoring.
Vitrified embryos, oocytes, sperm, and ovarian tissue require uninterrupted liquid nitrogen storage. A single warm excursion can trigger ice recrystallization and destroy viability.
CAR-T cells, leukapheresis collections, and hematopoietic stem cells demand cryogenic storage. Interim −80°C holds must be monitored to maintain post-thaw viability and therapeutic efficacy.
mRNA vaccines require ultra-cold storage at −80°C (Pfizer) or −20°C (Moderna) for months. Lipid nanoparticle integrity and RNA stability are directly tied to sustained temperature control.
The workhorse of biorepositories. DNA, RNA, plasma, serum, CSF, and tumor biopsies all depend on −80°C to prevent nucleic acid hydrolysis, protein denaturation, and metabolite breakdown.
Fresh frozen plasma requires storage below −30°C for up to one year, and below −60°C for up to seven years. Rare-phenotype red blood cells are stored in glycerol at −65 to −80°C.
Biological evidence integrity is critical for legal proceedings. Wildlife tissue archives, environmental DNA, and microbial community samples require verified ultra-cold chain documentation.
Once activated, the indicator turns bright pink and stays pink at safe temperatures. When heat thresholds are met, the color clears, giving you an unmistakable visual signal that conditions have been compromised.
“The Pinktail BX temperature indicators from CryoVeritas are a fantastic solution for our growing startup, allowing us to provide customers with peace of mind during shipping at a very economical price point. It even helped us diagnose a failing freezer during testing!”
Data loggers tell you what happened to a freezer. Indicators tell you what happened to your samples. That distinction can mean the difference between publishable data and a retraction.
Most facilities rely on ambient temperature sensors mounted to the wall or door of a freezer. These sensors measure air temperature at a single point — not the thermal state of your specimens deep inside a storage box.
During an excursion, samples at the center of a rack can remain frozen long after the alarm triggers, while samples near the door may already be compromised. Without an indicator inside the box, you're guessing which samples survived and which didn't.
Indicators bridge that gap by providing specimen-level evidence — a permanent, non-reversible record that travels with the sample from archival through retrieval, shipment, and downstream use.
Degraded RNA yields unreliable sequencing data. Compromised proteins produce misleading assay results. An indicator placed alongside your specimens ensures you never unknowingly build conclusions on damaged material — catching silent quality loss before it contaminates your research.
Regulatory frameworks — CAP, CLIA, FDA 21 CFR Part 211, and GxP — increasingly require documented proof of specimen integrity at the sample level. A tamper-evident, non-reversible color change provides photographable, auditable evidence that conditions were maintained throughout the storage lifecycle.
When a freezer alarm fires, the immediate question is: which samples are still usable? Without indicators, you either discard everything (costly) or assume everything is fine (risky). With an indicator in every box, triage is instant — clear indicators confirm integrity; changed indicators flag compromise.
Temperature indicators don't replace data loggers — they complement them. Loggers document facility performance; indicators document specimen experience. Together, they provide the complete picture that modern quality systems demand.
Indicators vs. Data LoggersRead about the science behind CryoVeritas indicators and the peer-reviewed research validating our approach.
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